Telerehabilitation In The Home After Stroke

Exclusion Criteria

• •1. A major, active, coexistent neurological, psychiatric, or medical disease that reduces the likelihood that a subject will be able to comply with all study procedures
• •2. Unable or unwilling to perform study procedures/therapy, or expectation of noncompliance with study procedures/therapy, or expectation that subject cannot participate in all study visits
• •3. A diagnosis (apart from the index stroke) that substantially affects paretic arm function
• •4. Severe depression, defined as Geriatric Depression Scale Score \>10/15 at Baseline Visit 1
• •5. Significant cognitive impairment, defined as Montreal Cognitive Assessment score \<22 \[a lower score is permitted if due to aphasia and allowed by the site PI\]
• •6. Deficits in communication that interfere with reasonable study participation
• •7. Severe UE spasticity, defined as presence of contracture or modified Ashworth Scale score=4 in either biceps or pectoralis
• •8. Modified Rankin Scale score was \>2 prior to the index stroke
• •9. A new symptomatic stroke has occurred since the index stroke, or a separate stroke occurred within 30 days prior to the index stroke
• •10. Lacking visual acuity, with or without corrective lens, of 20/50 or better in at least one eye
• •11. Life expectancy \< 9 months
• •12. Pregnant; women of child-bearing potential must have a negative pregnancy test
• •13. Botulinum toxin to the paretic arm: received in the prior 3 months OR expected by the 8-Month Visit
• •14. Concurrent enrollment in another therapy-based investigational study where the duration of the investigational therapy's activity is likely to occur during the subject's participation in the study
• •15. Subject lacks sufficient English or Spanish to comply with study procedures and TR instructions
• •16. Expectation that subject will not have a single domicile address during the 6 weeks of therapy that is within 1.5-hr drive of the central study site \[this can be waived at the discretion of the site PI\]
• •17. Contraindication to MRI
• •18. On isolation precautions, e.g., due to active COVID-19