Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial

Exclusion Criteria

• •Prescription sleeping medications or melatonin supplementation
• •Pregnant or lactating
• •Use of tobacco, nicotine or vaping products
• •Night shift work
• •On prescription aspirin
• •Severe lactose intolerance
• •History of substance use disorder
• •History of suicidal ideation
• •History of clinically diagnosed anemia (within the past 5 years) or low hemoglobin levels (\<11.6 g/dL) within the past 12 months
• •Active cancer
• •Severe daytime sleepiness (score \>15 at the Epworth Sleepiness Scale \[ESS\])81
• •Current or recent (within the past 2 months) participation in other research studies at the discretion of study investigators
• •Inability to provide written consent and/or to speak and read English
• •Any other medical, geographic, or social factor making study participation impractical