Loading clinical trials...

Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye Disease: a Randomized Trial | Clinical Trials | Clareo Health

COMPLETEDNA

Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye Disease: a Randomized Trial

NCT06745089•National Yang Ming Chiao Tung University

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to understand novel treatment methods for meibomian gland dysfunction (MGD)-associated dry eye disease (DED) by comparing two treatment modalities- intense pulsed light (IPL) and thermal pulsation therapy (TPT), to find out the difference of their therapeutic mechanisms and treatment effects, so that eye doctors can give more precise advice to the patients when making treatment decisions. The main questions it aims to answer are: * What subtype of meibomian gland dysfunction (MGD) better responds to which treatment modality? * How long do the treatment effects last? Researchers will compare each group (IPL and TPT) to a control group treated with eyedrops. \* Do combined treatment of IPL or TPT with eyedrops show better outcomes than only eyedrops? Participants will: * Receive different treatment for 2 months according to the group they were randomly allocated to. * Visit the clinic for checkups after 1 and 3 months after completing the treatment sessions.

Eligibility

Age

20 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•individuals diagnosed with meibomian gland dysfunction (MDG)-associated dry eye disease (DED) that are suitable for intense pulsed light (IPL) and thermal pulsation therapy (TPT)

Exclusion Criteria

•ocular surgery or trauma in the recent 3 months
•ocular infection
•eyelid abnormalities (e.g., entropion, ectropion, lagophthalmos, severe ptosis or trichiasis)
•blepharospasm
•eyelid tumor
•severe meibomian gland atrophy
•allergic to topical anesthetics
•sunbathe in recent one month
•periocular fillers

Locations (1)

Institute of Biophotonics, National Yang Ming Chiao Tung University

Taipei, Taiwan

Key Dates

Start Date

July 13, 2022

Primary Completion Date

June 21, 2023

Completion Date

March 10, 2024

Last Updated

December 20, 2024

Enrollment

ACTUAL participants

Conditions

Dry Eye Disease (DED)Meibomian Gland Dysfunction

Interventions

Intense pulsed light

DEVICE

thermal pulsation therapy

DEVICE

Ocular lubricant

DRUG

A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study

NCT07463950

Dry Eye Disease (DED)

View study

RECRUITINGPHASE4

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

NCT07396441

Juvenile Open Angle GlaucomaDry Eye Disease (DED)+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 20, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye Disease: a Randomized Trial

Inclusion Criteria

Exclusion Criteria

A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

Role of Corneal Nerves in Dry Eye Disease

Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD

Moderate-to-Severe Dry Eye Disease Relief Using Acoltremon

Single Lipiflow Treatment to Reduce Pharmacologic Burden in DED