Safety and Tolerability of LDRT+Sugemalimab+Chemotherapy+Olaparib for First-Line Treatment of SLFN-11 Positive ES-SCLC

Exclusion Criteria

• •1. Histopathologic or cytopathologic diagnosis of mixed small cell lung cancer or non-small cell lung cancer
• •2. Limited stage small cell lung cancer
• •3. Combination of poorly controlled malignant pleural or pericardial effusions requiring continuous drainage
• •4. Presence of active or symptomatic brain metastases or Leptomeningeal metastases
• •5. Prior systemic antitumor therapy (chemotherapy, targeted agents such as PARP inhibitors) or immune checkpoint inhibitors for SCLC
• •6. Presence of active, unstable systemic disease such as active infection, autoimmune disease, inflammatory disease (uncontrolled hypertension, heart failure (NYHA classification \>= Class II), unstable angina, acute coronary syndrome, severe arrhythmia, severe hepatic, renal or metabolic disease, human immunodeficiency virus (HIV) immunodeficiency virus (HIV) infected patients
• •7. Previous allogeneic stem cell or solid organ transplantation
• •8. Patients with prior interstitial lung disease, drug-induced interstitial lung disease, or active interstitial pneumonia requiring systemic glucocorticoid or immunosuppressive therapy; Patients with pulmonary interstitial fibrosis or active pulmonary tuberculosis
• •9. Severe infection within 4 weeks prior to the start of study treatment, including but not limited to hospitalization for infection, bacteremia, or severe pneumonia
• •10. Received therapeutic oral or intravenous infusion of antibiotics within 2 weeks prior to the start of study treatment
• •11. Been diagnosed or treated for another malignancy (excluding resected basal cell carcinoma of the skin or other carcinoma in situ) within 5 years prior to randomization to this study
• •12. For pregnant or lactating females or male or female subjects of reproductive potential who refuse to use effective contraception during treatment and within 5 months of the last dose of sugemalimab and within 6 months of the last dose of cisplatin or etoposide
• •13. Allergic to the study drug or its components
• •14. The investigator believes that the patients may not be able to complete the study or comply with the requirements of the study
• •15. Inadequate bone marrow function and vital organ function reserve
• •16. Concurrent participation in another clinical study, unless it is an observational (non-interventional) clinical study or a follow-up phase of an interventional study, excluding patients who have received any other experimental drug within 28 days prior to the start of study treatment
• •17. Patients who are not suitable for etoposide-cisplatin chemotherapy, sugemalimab or olaparib
• •18. History of thoracic radiotherapy or plan to receive intensive thoracic radiotherapy prior to systemic therapy. External chest radiotherapy for palliative purposes (e.g., bone metastases) is allowed, but must be completed prior to the first administration of study drug