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Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy

Efficacy of Adding Ketamine to Levobupivacaine in Paravertebral Block on Acute and Chronic Pain in Thoracotomy: a Randomized Controlled Double-blinded Trial

NCT06011746•Tanta University

View on ClinicalTrials.gov

Summary

To evaluate the role of adding ketamine to levobupivacaine in PVB on acute and chronic pain in thoracotomy

Detailed Description

Several adjuvants have been added to them to enhance the effects of those blocks. Dexamethasone, morphine, dexmedetomidine, clonidine, ketamine, and magnesium sulphate are some of them. results are variable. Ketamine blocks N-Methyl-D-Aspartate (NMDA) receptors in the spinal cord. It is also considered to influence voltage sensitive Calcium ions channels, opioid receptors, and monoaminergic receptors. Therefore, it is considered overall to affect nociception.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age 18-75 years.
•Both sexes.
•ASA (American Society of Anesthesiology) physical status II-III.
•Scheduled for open thoracotomy.

Exclusion Criteria

•Contraindications to or failed paravertebral block .
•Body mass index (BMI) \>35 kg/m2.
•The likelihood of postoperative mechanical ventilation.
•Patients with coagulopathy, poorly controlled diabetes mellitus, depression or other psychiatric disorders that required antidepressant drugs, alcohol, or recreational drug addiction.
•Hypersensitivity to ketamine or levobupivacaine.

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt

Key Dates

Start Date

August 30, 2023

Primary Completion Date

January 26, 2024

Completion Date

January 26, 2024

Last Updated

February 13, 2024

Enrollment

ACTUAL participants

Conditions

KetamineLevobupivacaineParavertebral BlockAcute PainChronic Pain

Interventions

Ketamine + Levobupivacaine

DRUG

Levobupivacaine

DRUG

Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.

NCT07461376

Pediatric SedationClonidine Sedation+1 more

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RECRUITING

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

NCT07222007

Critically IllIntubation Complication+4 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 13, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy

Inclusion Criteria

Exclusion Criteria

Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain

Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery