Chronic Pain Clinical Trials

Showing 1-20 of 835 trials

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

NCT06382272

This trial seeks to establish whether or not touch sensation can be restored to the breast via neural stimulation. Data will also be obtained to inform future feasibility (including safety), efficacy, and acceptability trials.

MastectomyBreastChronic Pain

University of Chicago8 participantsStarted May 2025

Chicago, Illinois, United States

TERMINATEDNA

Effect of Guanfacine on the Reversal of Opioid-induced Hyperalgesia (OIH)

NCT02192398

Combination of guanfacine with opioid medication as a standard treatment for chronic pain.

Chronic Pain

Massachusetts General Hospital8 participantsStarted Sep 2014

Boston, Massachusetts, United States

RECRUITINGNA

Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block

NCT07368413

This prospective randomized study will compare the effects of Erector Spinae Plane Block (ESPB) and Serratus Anterior Plane Block combined with Pectoral Nerve Block Type II (SAPB + PECS II) on intraoperative analgesia and postoperative opioid consumption in patients undergoing breast cancer surgery. Seventy patients (ASA I-III, aged 18-75 years) will be randomized into two groups using the sealed envelope method. Ultrasound-guided blocks will be performed preoperatively by the same anesthesiologist, with Group 1 receiving ESPB and Group 2 receiving a combined SAPB + PECS II technique performed through a single skin puncture (single needle entry site) with sequential injections into the two target fascial planes. All patients will undergo surgery under general anesthesia and receive postoperative analgesia via morphine patient-controlled analgesia. Pain scores and total opioid consumption will be statistically analyzed, with p \< 0.05 considered significant.

Pain Management in Breast SurgeryPain After SurgeryRegional Anaesthesia

Kayseri City Hospital70 participantsStarted Apr 2026

Kayseri, Kocasinan, Turkey (Türkiye)

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

Effect of Guanfacine on the Reversal of Opioid-induced Hyperalgesia (OIH)

Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block

Related Searches

Tapering From Long-term Opioid Therapy in Chronic Pain Population. Randomized Controlled Trial With 12 Months Follow up

Enhancing Health in Rural Populations: Music as Therapy

Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes

Reboot Pain (tDCS)

Cannabidiol in Opioid Use Disorder and Chronic Pain

Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures

Cohort of Chronic Pain Patients

Effects of Spinal Cord Stimulation

IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs

Inflammatory Markers in Lumbar Radicular Pain Treated With PRF and TFESI

Comparison of Intrathecal Morphine and Rectus Sheath Block for Postoperative Pain Management After Lower Abdominal Surgery With Midline Incision

Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain

Methadone Pharmacokinetics in Cardiac Surgery

Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center)

Splinting vs Exercise in De Quervain's Tenosynovitis

Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy