Cohort Study of Inpatients and Outpatient Patients With Cerebral Small Vessel Disease

Exclusion Criteria

• •1. Diagnosis of symptomatic lacunar syndrome without 6 months of onset (participants can be enrolled after 6 months to avoid the impact of the acute phase).
• •2. Intracranial and extracranial vascular examination confirms stenosis of the blood vessel by ≥50%.
• •3. Imaging data reveals intracranial space-occupying lesions.
• •4. A history of other neurological or mental illnesses with a definite diagnosis of the cause, including stroke (excluding lacunar infarctions), neurodegenerative diseases (such as Parkinson's disease and Alzheimer's disease).
• •5. Co-occurring serious illnesses, such as malignant tumors, heart failure, respiratory failure, renal failure, severe liver dysfunction, severe blood system diseases, or gastrointestinal bleeding.
• •6. Severe impairment in vision, hearing, language function, or limb muscular weakness that prevents completion of relevant tests.
• •7. Women who are pregnant or breastfeeding.
• •8. MRI scan contraindicated due to various reasons (such as claustrophobia).
• •9. Any other reasons that prevent the collection of clinical data required for this study.