Registry Study of Cerebral Small Vessel Disease

Exclusion Criteria

• •1. Patients with acute ischemic stroke or acute intracranial hemorrhage (e.g., epidural hematoma, subdural hematoma, subarachnoid hemorrhage, intracerebral hemorrhage, etc.) or a history of cerebral infarction (non-lacunar) or intracranial hemorrhage within the past 3 months;
• •2. Significant non-vascular white matter lesions (e.g., multiple sclerosis, adult-onset leukoencephalopathy, metabolic encephalopathy, etc.);
• •3. Patients with a history of cognitive impairment due to other causes (e.g., normal pressure hydrocephalus, Alzheimer's disease, Parkinson's disease, multiple sclerosis, encephalitis, etc.);
• •4. Severe hepatic, renal, or cardiac insufficiency (ALT or AST \>2 times the upper limit of normal, or serum creatinine \>1.5 times the upper limit of normal, or New York Heart Association \[NYHA\] functional class III or IV);
• •5. Patients with psychiatric disorders that affect study medication administration and evaluation;
• •6. Contraindications to MRI examination (e.g., claustrophobia, presence of an implantable pacemaker, etc.);
• •7. Patients unable to comply with follow-up examinations or other study procedures due to residential location or other reasons;
• •8. Participation in other clinical trial projects.