Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years

Inclusion Criteria

• •1. Patients with any of the CSVD-related MRI imaging markers, including recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and superficial cortical siderosis.
• •2. Patients aged from 30 to 60 years.
• •3. Sign informed consent.
• •2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator.
• •3. Any adverse or serious adverse events during the study period judged by investigator.