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Nut Supplementation to Mitigate Post-stroke Cognitive Decline (NUT-me): a Pilot Study
Stroke is a strong risk factor for dementia, with up to 80% of individuals having lower cognitive function 5 years after a stroke event. However, having a stroke does not need to result in declining cognition if effective strategies to reduce the risk of post stroke dementia are identified. Diets containing nuts can reduce the risk of both dementia and stroke but have not been tested in stroke survivors. Therefore, this pilot study aims to determine whether eating nuts regularly reduces post-stroke cognitive decline and dementia. The NUT-me pilot study will supplement the diet of stroke survivors with a mix of nuts containing walnuts, hazelnuts, almonds and Brazil nuts for 3 months and assess the effects on cognition and health markers. The researchers predict that regular nut consumption will contribute to preserving post-stroke cognitive function in comparison to patients who do not consume nuts. The results of this novel pilot study will be used to guide a larger trial and provide a simple dietary strategy that stroke survivors can adopt to reduce post-stroke cognitive decline.
This study will investigate the efficacy and feasibility of supplementing the habitual diet of stroke survivors with a supply of mixed nuts containing Brazil nut, walnuts, hazelnuts, and almonds to reduce post-stroke cognitive decline. The overall aim of this project will be achieved through the following objectives: * Examine the feasibility through the assessment of compliance with the intervention and participants' perception of the study * Investigate the efficacy of the intervention on cognitive decline, body composition and health outcomes (blood pressure, fasting glucose and insulin, and blood lipids) The investigators hypothesise that the inclusion of nuts is a simple dietary strategy that will slow post-stroke cognitive decline and that supplementation with nuts will improve body composition and health biomarkers of stroke survivors.
Age
18 - 99 years
Sex
ALL
Healthy Volunteers
No
Department of Nutrition, Dietetics and Food - Monash University
Melbourne, Victoria, Australia
Start Date
June 30, 2023
Primary Completion Date
June 30, 2027
Completion Date
December 30, 2027
Last Updated
November 22, 2024
10
ESTIMATED participants
Nuts
OTHER
Control
OTHER
Lead Sponsor
Monash University
NCT06258538
NCT07371455
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT05093673