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Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"What are the potential side effects of dexpramipexole compared to my current medications?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma. clinical trial (NCT05763121). Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"How will this trial affect my current asthma management plan?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma. clinical trial (NCT05763121). 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Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"How will my progress be monitored throughout the study?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma. clinical trial (NCT05763121). Contact the study team or your healthcare provider for specific answers."}}]}27:["$","script","3",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$29"}}] 2b:T2578,Inclusion Criteria: 1. Signed informed consent form and assent form, as appropriate 2. Male or female ≥12 years of age at Screening Visit 1 Asthma-related criteria 3. Documented physician diagnosis of asthma for ≥12 months prior to Screening Visit 1. 4. Treatment of asthma, participants must satisfy all the below (items a to c): 1. Participants who have received asthma controller medication with medium or high dose inhaled corticosteroids (ICS; ≥500 μg/day fluticasone propionate dry powder formulation daily or clinically comparable, per Global Initiative for Asthma (GINA) 2021) on a regular basis for at least 12 months prior to Screening Visit 1. 2. Documented treatment with a stable dose of either medium or high dose ICS for at least 3 months prior to Screening Visit 1. The ICS may be contained within an ICS/LABA (long-acting β2 agonist) combination product. Daily oral corticosteroids are an allowed concomitant medication; participants on daily oral corticosteroids must be on a stable dose for 3 months before Screening Visit 1. 3. Use of one of more additional daily maintenance asthma controller medications according to standard practice of care is required. Use of a stable dose of any additional asthma controller medications must be documented for at least 3 months prior to Screening Visit 1. 5. Pre-bronchodilator forced expiratory volume (Pre-BD FEV₁) ≥40% and \<80% (\<90% for participants 12 to 17 years of age) of predicted at Screening Visit 2. 6. Variable airflow obstruction documented with at least one of the following criteria: 1. Bronchodilator reversibility at Screening Visit 2, as evidenced by ≥12% and ≥200 mL improvement in FEV₁, 15 to 30 minutes following inhalation of 400 μg (four puffs) of albuterol/salbutamol (≥12% and ≥160 mL for ages 12 to17). Participants who do not meet the bronchodilator reversibility inclusion criterion but have ≥10% and ≥160 mL reversibility, may repeat the reversibility spirometry assessment once during the Screening period, at an unscheduled visit at least 7 days prior to baseline. 2. Bronchodilator reversibility, using the criteria above, documented in the past 24 months prior to Screening Visit 1. 3. Peak flow variation of ≥20% over a 2-week period, documented in the past 24 months prior to Screening Visit 1. 4. Airflow variability in clinic FEV₁ ≥20% between two consecutive clinic visits, documented in the past 24 months prior to Screening Visit 1. 5. Airway hyperresponsiveness (provocative concentration causing a 20% fall in FEV₁ of methacholine \<8 mg/mL) documented in the past past 24 months prior to Screening Visit 1. 7. ACQ-6 ≥1.5 at Screening Visit 2. 8. Documented history of at least two asthma exacerbations requiring treatment with systemic corticosteroids (intramuscular, intravenous, or oral) within the past 12-month period prior to Screening Visit 1. General medical history 9. Negative urine pregnancy test for women of childbearing potential (WOCBP; after menarche) at the Screening Visit 2 and Baseline Visit. 10. WOCBP must use either of the following methods of birth control, from Screening Visit 1 through the End of Study Visit: 1. A highly effective form of birth control (confirmed by the investigator). Highly effective forms of birth control include: true sexual abstinence, a vasectomized sexual partner, Implanon, female sterilization by tubal occlusion, any effective Intrauterine device (IUD), IUD/intrauterine system (IUS), Levonorgestrel Intrauterine system, or oral contraceptive. Or 2. Two protocol acceptable methods of contraception in tandem. Women not of childbearing potential are defined as women who are either permanently sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingectomy), or who are postmenopausal. Women will be considered postmenopausal if they have been amenorrheic for ≥12 months prior to the planned date of the Baseline Visit without an alternative medical cause. The following age specific requirements apply: 3. Women \<50 years old would be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatment and follicle stimulating hormone levels in the postmenopausal range. 4. Women ≥50 years old would be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatment. Exclusion Criteria: Asthma-related criteria 1. A participant who experiences a severe asthma exacerbation (defined as a deterioration of asthma that results in emergency treatment, hospitalization due to asthma, or treatment with systemic corticosteroids) at any time from 4 weeks prior to Screening Visit. Participants who experience an asthma exacerbation during the Screening/Run-in Period may remain in screening and proceed with study visits 14 days after they have completed their course of oral steroids or returned to their pre-Screening Visit maintenance dose of oral steroids and the investigator considers participant has returned to baseline status. 2. Current diagnosis of diseases which may confound interpretation of this study's findings such as allergic bronchopulmonary aspergillosis, eosinophilic granulomatosis with polyangiitis, eosinophilic gastrointestinal diseases, hypereosinophilic syndrome, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis. 3. Respiratory infection: Upper or lower respiratory tract, sinus, or middle ear infection within the 4 weeks before Screening Visit 1. 4. For participants aged 12 to 17 years old, AEC of \<0.15x10⁹/L at Screening Visit 1. Prohibited medications/procedures 5. Treatment with a biologic investigational drug in the last 5 months prior to Screening Visit 1. Treatment with non-biologic investigational drugs in the previous 30 days or five-half-lives prior to Screening Visit 1, whichever is longer. Treatment with GSK3511294 (long-acting anti-IL-5) in the past 12 months. 6. Treatment with any of the following monoclonal antibody therapies within 120 days prior to Baseline Visit: benralizumab, dupilumab, mepolizumab, reslizumab, omalizumab, tezepelumab, or tralokinumab. 7. Treatment with pramipexole (Mirapex®) within 30 days of Baseline Visit. 8. Treatment with selected drugs known to have a substantial risk of neutropenia in the past 30 days prior to Screening Visit 1. 9. Bronchial thermoplasty procedure in the past 12 months prior to Screening Visit 1 or planned during the coming year. General medical history 10. Weight \<40 kg at Screening Visit 2. 11. Current smoking within the 12 months prior to Screening Visit 1 or a smoking history of \>10 pack-years. Smoking includes tobacco, vaping, and/or marijuana use. 12. Known or suspected alcohol or drug abuse 13. Uncontrolled severe hypertension: systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg prior to the Baseline Visit despite antihypertensive therapy. 14. History of malignancy that required surgery (excluding local and wide-local excision), radiation therapy and/or systemic therapy during the 5 years prior to the Baseline Visit. 15. History of human immunodeficiency virus (HIV) infection or chronic infection with hepatitis B or C. 16. A helminth parasitic infection diagnosed within 24 weeks prior to Screening Visit 1 that has not been treated with or has failed to respond to standard of care (SoC) therapy. 17. Medical or other condition likely to interfere with participant's ability to undergo study procedures, adhere to visit schedule, or comply with study requirements. 18. Known or suspected noncompliance with medication. 19. Unwillingness or inability to follow the procedures outlined in the protocol. Clinical safety labs 20. Absolute neutrophil count (ANC) \<2.000x10⁹/L at Screening Visit 1 or Screening Visit 2. 21. Renal dysfunction, defined as an estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73m² at Screening Visit 2 (using the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] formula for age ≥18 years at screening; using the Bedside Schwartz eGFR formula). 22. Active liver disease defined as any known current infectious, neoplastic, or metabolic pathology of the liver or unexplained elevations in alanine aminotransferase (ALT), aspartate aminotransferase (AST), \>3x the upper limit of normal (ULN), or total bilirubin \>2x ULN at Screening Visit 2 confirmed by a repeat abnormal measurement of the relevant value(s), at least 1 week apart. Cardiac safety 23. History of New York Heart Association class IV heart failure or last known left ventricular ejection fraction \<25%. 24. History of major adverse cardiovascular event (MACE) within 3 months prior to the Baseline Visit. 25. History of cardiac arrhythmia within 3 months prior to the Baseline Visit that is not controlled by medication or via ablation. 26. History of long QT syndrome. 27. Corrected QT interval by Fridericia (QTcF) interval \>450 ms for males and \>470 ms for females at Screening Visit 2 or QTcF ≥480 ms for participants with bundle branch block. 28. Clinically important abnormalities in resting ECG that may interfere with the interpretation of QTcF interval changes at Screening Visit 2, including heart rate \<45 beats per minute (bpm) or \>100 bpm. Pregnancy/Lactation 29. Pregnant women or women breastfeeding 30. Males who are unwilling to use an acceptable method of birth control during the entire study period (ie, condom with spermicide).28:["$","$L2a",null,{"trial":{"nctId":"NCT05763121","briefTitle":"A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.","officialTitle":"A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 52 Weeks in Participants With Severe Eosinophilic Asthma","briefSummary":"This study will assess the efficacy and safety of dexpramipexole as an adjunctive oral therapy in participants with inadequately controlled asthma with an eosinophilic phenotype and a history of asthma exacerbations.","detailedDescription":"This is a multicenter, randomized, double-blind, placebo controlled, parallel group study designed to evaluate the efficacy and safety of dexpramipexole in adults and adolescents with severe, inadequately controlled asthma with eosinophilic phenotype on medium to high-dose inhaled corticosteroids (ICS )and at least one additional asthma controller medication with or without oral corticosteroids (OCS). 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The study aims to see if dexpramipexole can improve asthma symptoms compared to a placebo over a period of 52 weeks.","version":2,"mainIdea":"Assessing effectiveness and safety","studyAbout":"This clinical trial is testing dexpramipexole, a new oral medication, in people aged 12 and older who have severe eosinophilic asthma that is not well controlled. The study aims to see if dexpramipexole can improve asthma symptoms compared to a placebo (a dummy treatment) over a period of 52 weeks.","comparedWith":"Placebo","mayQualifyIf":["You have severe eosinophilic asthma that hasn't been well controlled with current treatments.","Your asthma requires medium to high doses of inhaled corticosteroids and additional asthma medications.","You have experienced asthma flare-ups that needed treatment with steroids in the past year.","You are between 12 and 99 years old and are looking for new treatment options."],"newTreatment":"Dexpramipexole","lessRelevantIf":["You have had a severe asthma attack recently that required emergency treatment.","You are currently taking certain asthma medications that are not allowed in this study.","You have other serious health conditions that could affect your asthma treatment.","You are pregnant or breastfeeding."],"questionsToAsk":["Am I eligible for this trial based on my current asthma treatment?","What are the potential side effects of dexpramipexole compared to my current medications?","How will this trial affect my current asthma management plan?","What are the logistics of participating, including visits and treatments?","What should I do if I experience an asthma flare-up during the trial?","How will my progress be monitored throughout the study?"],"careConversation":"This study could be an important option for patients struggling with severe eosinophilic asthma who are not achieving control with current therapies. Discussing this trial with your oncologist may help you explore new treatment avenues, weigh the benefits and risks, and consider how it fits into your overall asthma management plan, including potential side effects and the commitment involved in participating.","worthDiscussingIf":["You have severe eosinophilic asthma that hasn't been well controlled with current treatments.","Your asthma requires medium to high doses of inhaled corticosteroids and additional asthma medications.","You have experienced asthma flare-ups that needed treatment with steroids in the past year.","You are between 12 and 99 years old and are looking for new treatment options."],"likelyWontQualifyIf":["You have had a severe asthma attack recently that required emergency treatment.","You are currently taking certain asthma medications that are not allowed in this study.","You have other serious health conditions that could affect your asthma treatment.","You are pregnant or breastfeeding."],"participationBullets":["Participants will take either dexpramipexole or a placebo tablet daily for a year.","Regular visits will include assessments of asthma control and lung function tests.","Participants will need to keep track of their asthma symptoms and any flare-ups.","There will be a follow-up period of 4 weeks after the treatment ends to monitor health."],"participationDetails":{"visitRhythm":"Every 4 weeks for 52 weeks, plus a follow-up visit 4 weeks after treatment ends.","treatmentLength":"52 weeks","participationCycles":"1 cycle"},"whatParticipatingInvolves":["Participants will take either dexpramipexole or a placebo tablet daily for a year.","Regular visits will include assessments of asthma control and lung function tests.","Participants will need to keep track of their asthma symptoms and any flare-ups.","There will be a follow-up period of 4 weeks after the treatment ends to monitor health."]},"aiSummaryGeneratedAt":"$D2026-07-13T05:43:33.523Z","id":"c7ffb951-c997-45ac-b160-9a6ea668e4e1","createdAt":"$D2026-03-23T11:08:58.128Z","updatedAt":"$D2026-07-13T05:43:33.523Z"}}]

What this study is about