CerebrAlcare Pills on CereBral Small VesseL DiseasE（CABLE）

Exclusion Criteria

• •1. Cerebral hemorrhage and subarachnoid hemorrhage occurred within 30 days.
• •2. Symptomatic middle cerebral artery and/or internal carotid artery stenosis, stenosis rate ≥ 50%; asymptomatic middle cerebral artery and/or internal carotid artery stenosis, stenosis rate ≥ 70%.
• •3. Coronary CTA or coronary angiography showed severe three vessel lesions or frequent angina pectoris within 30 days.
• •4. Chronic kidney disease stage 4 or 5.
• •5. Resistant hypertension which could not be controlled by medicine (SBP \> 180mmHg or DBP \> 110mmHg).
• •6. Resistant hyperglycemia which could not be controlled by medicine（fasting blood glucose \> 10mmol/L or HB1AC \> 7%).
• •7. In acute cerebral infarction, the lesions showed high signal intensity on DWI, and the diameter was more than 20 mm or history of assive cerebral infarction within 30 days.
• •8. Neurodegenerative diseases, such as AD and PD, have been diagnosed.
• •9. There are clear non angiogenic white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy diseases, etc.
• •10. Untreated cerebrovascular malformations or intracranial aneurysms (d \> 3mm).
• •11. Active gastrointestinal bleeding.
• •12. Coagulation dysfunction or history of systemic bleeding.
• •13. Hemorrhagic tendency (including but not limited to)：PLT\<100×109/L; heparin treatment within 48h; APTT ≥ 35s; current use of warfarin, INR \> 1.7; current use of novel oral anticoagulants; current use of direct thrombin or factor Xa inhibitor.
• •14. Severe hepatic or renal or heat insufficiency before randomization (severe hepatic insufficiency refers to ALT or AST \> 2 times the upper limit of normal; severe renal insufficiency refers to serum creatinine\> 1.5 times the upper limit of normal or eGFR\<40 ml/min/1.73m2; severe heat insufficiency refers to NYHA stage 3 and 4).
• •15. History of intracranial or intramedullary surgery within three months of randomization.
• •16. The patient has used or is using chinese medicine with similar components to CerebrAlcare pill/granule (including Tianshu capsule, Toutongning capsule, Naoxintong capsule, Danzhen Toutou capsule, Yindanxinnaotong soft capsule, Naoxinqing Tablet, Bazhen pill and Shiquandabu pill) within 14 days.
• •17. Definite indications for anticoagulation (suspicion of cardioembolism, e.g. atrial fibrillation, known heart valve prosthesis, atrial myxoma, endocarditis, etc.) or definite indications for dual antiplatelet therapy (e.g. recent coronary or cerebral artery stent implantation).
• •18. Other surgical or interventional therapy planned within 1 year requiring experimental drugs discontinuation.
• •19. Childbearing-age women who do not take effective methods of contraception without negative records of pregnancy tests.
• •20. Known to be allergic to CerebrAlcare pill/granule.
• •21. Contraindications of MRI examination (such as claustrophobia).
• •22. With severe organic diseases, such as malignant tumor, the expected survival time is less than 1 years.
• •23. Due to geographical or other reasons can not cooperate to complete the follow-up.
• •24. Patients also participated in other clinical trials.