A Phase I Clinical Trial of Bevacizumab Injection

Exclusion Criteria

• •1 Have a history of hypertension or abnormal blood pressure during screening / baseline measurement(Repeated measurements on the same day confirmed that systolic blood pressure \[SBP\] \> 140 mmHg and / or diastolic blood pressure \[DBP\] \> 90 mmHg).
• •2 Clinically significant proteinuria (routine urine examination, urine protein 2+ and above) or history of proteinuria assessed by the investigator.
• •3 Have received any antibody or protein therapy targeting VEGF or VEGF receptor in the past 1 year.
• •4 Used any biological products or vaccinated with live virus vaccine within 3 months before the infusion of the study drug, or used any monoclonal antibody within 12 months.
• •5 Have hereditary bleeding tendency or coagulation dysfunction, or have a history of thrombosis or bleeding.
• •6 Have a history of gastrointestinal perforation or fistula.
• •7 Unhealed wound ulcer or fracture, or major surgery within the first 2 months of randomization, or major surgery expected during the study period or within 2 months after the end of the study.
• •8 Use prescription or over-the-counter drugs or nutritional health products, and the use time is within 5 half lives of the drugs or nutritional health products or within 2 weeks before the use of the study drugs (the time limit is whichever is longer).Herbal health products should be stopped 28 days before using the study drug.
• •9 Hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody or syphilis antibody are tested positive.
• •10 Known allergy to bevacizumab or any of its excipients.
• •11 People with known history of allergic diseases or allergic constitution.
• •12 There was a history of blood donation 3 months before the infusion of the study drug.
• •13 Have been treated with any other research drugs or participated in another intervention clinical trial within 2 months before screening.
• •14 Have a history of alcohol or drug abuse within 12 months before screening; The subjects were unable to quit drinking within 72 hours before administration and throughout the trial.
• •15 Have a history of mental illness.
• •16 Subjects whose spouses plan to conceive.
• •17 Unable to follow the protocol requirements to complete the study during the study.
• •18 Other researchers think it is not suitable to be included in the group