Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.

Inclusion Criteria

• •1. Written informed consent to participate in the study;
• •2. Age 40 and over;
• •3. Male and female;
• •4. One or more cardiovascular pathologies in the anamnesis:
• •* a reliably confirmed diagnosis of hypertension, stage I-III (the diagnosis was made in accordance with the National Clinical Guidelines - 2019);
• •* stable angina pectoris I-III functional class, confirmed by complaints, anamnesis and physical examination and with the help of diagnostic tests (bicycle ergometry or daily electrocardiography monitoring);
• •* confirmed diagnosis of arrhythmias and conduction disorders based on electrocardiography data and 24-hour Holter monitoring (premature depolarization, supraventricular tachycardia, atrial fibrillation, sick sinus syndrome, atrioventricular block I-II, bundle branch blocks);
• •* chronic heart failure stage I-IIB, I-III functional class (New York Heart Association Functional Classification), confirmed by the presence of clinical signs and at least one of two criteria: myocardial dysfunction of left ventricle or / and an increase in the level of the N-terminal fragment of brain natriuretic peptide over 125 pg / ml;
• •* the presence of signs of systolic or diastolic dysfunction of the left ventricle according to echocardiography.
• •5. COVID-19 infection confirmed by laboratory tests (polymerase chain reaction testing, enzyme-linked immunosorbent assay (positive result at least 1 time) with a CT degree of 3 or higher.
• •1. Acute infectious diseases, tuberculosis;
• •2. Chronic somatic diseases in the acute stage;
• •3. Congenital anomalies of the heart and large vessels;
• •4. Valvular heart defects (congenital and acquired);
• •5. Severe atherosclerosis of the lower extremities'vessels (chronic ischemia of the lower extremities,stage 3-4);
• •6. Acute decompensated heart failure (II-IV class according to Killip classification);
• •7. Chronic heart failure IV functional class (New York Heart Association Functional Classification classification);
• •8. Secondary arterial hypertension;
• •9. Acute coronary syndrome within 4 weeks before the start of the study;
• •10. Life-threatening rhythm and conduction disturbances;
• •11. Bronchial asthma with the development of respiratory failure II-III degree;
• •12. Acute cerebrovascular accident within the last 4 months;
• •13. Chronic kidney disease (glomerular filtration rate\<30 ml / min / 1.73 m2 via CKD-EPI (chronic kidney disease epidemiology collaboration) formula);
• •14. Pregnancy;
• •15. Mental illness (severe dementia, schizophrenia, severe depression, manic-depressive psychosis);
• •16. Oncology, diagnosed within a year or receiving a course of radiation / chemotherapy for cancer at the present time;
• •17. Severe cognitive impairment (MOS) and clinically significant anxiety and / or depression (HADS) interfering with observation;
• •18. Individual intolerance to oxygen deficiency.