Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease

Exclusion Criteria

• •For Extensive cSVD patient group :
• •1. For the extensive cSVD patient group also included in the LEOPOLD trial:
• •* patients with severe myopia greater than -6 dioptres
• •* partients with known allergy to Tropicamide (Mydriaticum®)
• •* patients with an extensive cataract
• •* patients with ptosis
• •2. For the extensive cSVD patient group not included in the LEOPOLD trial:
• •* Orthostatic hypotension defined by a decrease of 20 mmHg in SBP and / or 10 mmHg in DBP in a standing position at 3 minutes sought in the previous 3 months or on the day of inclusion,
• •* Very severe renal impairment (creatinine clearance less than 15 ml / min) on a blood test dating back less than one year,
• •* Secondary hypertension: renovascular hypertension, primary hyperaldosteronism, pheochromocytoma...
• •* Contraindication to MRI (presence of a ferromagnetic foreign body, in particular certain intracranial clips, certain heart valves, an intraocular foreign body, metal prosthesis, subject carrying a pacemaker, subject carrying prosthetic heart valves incompatible with MRI. ventricular shunt, claustrophobia),
• •* Associated severe diseases, with a life expectancy of less than 3 months,
• •* Physical problems likely to interfere with the feasibility of the tests (sight, hearing, etc.),
• •* Existence of dementia of which the etiology is distinct from Alzheimer's disease, vascular or mixed dementia
• •* Persons under tutorship or curatorship,
• •* Patients with loss of autonomy living in EHPAD (nursing home)
• •* patients with severe myopia greater than -6 dioptres
• •* participants with known allergy to Tropicamide (Mydriaticum®)
• •* patients with an extensive cataract
• •* patients with ptosis
• •For the minimal cSVD patient group:
• •Orthostatic hypotension defined by a decrease of 20 mmHg in SBP and / or 10 mmHg in DBP in a standing position at 3 minutes sought in the previous 3 months or on the day of inclusion,
• •Very severe renal impairment (creatinine clearance less than 15 ml / min) on a blood test dating back less than one year,
• •Secondary hypertension: renovascular hypertension, primary hyperaldosteronism, pheochromocytoma...
• •Contraindication to MRI (presence of a ferromagnetic foreign body, in particular certain intracranial clips, certain heart valves, an intraocular foreign body, metal prosthesis, subject carrying a pacemaker, subject carrying prosthetic heart valves incompatible with MRI. ventricular shunt, claustrophobia),
• •Associated severe diseases, with a life expectancy of less than 3 months,
• •Physical problems likely to interfere with the feasibility of the tests (sight, hearing, etc.),
• •Existence of dementia of which the etiology is distinct from Alzheimer's disease, vascular or mixed dementia
• •Persons under tutorship or curatorship,
• •Patients with loss of autonomy living in EHPAD (nursing home)
• •Patients with severe myopia greater than -6 dioptries
• •Patients with known allergy to Tropicamide (Mydriaticum®)
• •Patients with an extensive cataract
• •Patients with ptosis