China Imaging-based Biobank of Cerebral Small Vessal Diseases

Inclusion Criteria

• •1. Age ≥ 18 years old
• •2. SVD lesions can be seen on MRI of the head
• •* White matter hyperintensity, Fazekas score ≥ 2
• •* Fazekas=1 has more than 2 vascular risk factors (hypertension, hyperlipidemia, diabetes, obesity, smoking, and other vascular events except stroke).
• •* Fazekas = 1 and combined with lacunar focus
• •* Imaging findings suggest new subcortical lacunar infarction
• •3. Daily life independence (MRS ≤ 2)
• •4. Sign informed consent
• •Note: the imaging definition of small vessel disease refers to the strong guideline
• •1. The total score of Fazekas was 6, which was the sum of Fazekas scores of subcortical and periventricular white matter lesions.
• •2. New subcortical lacunar infarction: head MRI examination, subcortical, basal ganglia or brain stem DWI showed high signal (ADC diffusion limited) lesions with diameter \< 20 mm, with or without corresponding clinical symptoms; There were new clinical symptoms. FLAIR sequence of head MRI showed flair hyperintense lesions (diameter \< 20 mm) in subcortical, basal ganglia or pons.