Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization

Exclusion Criteria

• •1. ST-elevation myocardial infarction (STEMI) at presentation
• •2. Cardiogenic shock or severe hemodynamic instability at the time of intervention (heart rate\<50 beats per minute, systolic blood pressure \<90mmHg) or use of left ventricular assist device
• •3. Any target vessel with a distal Thrombolysis In Myocardial Infarction (TIMI) flow \<3.
• •4. Presence of thrombus in intermediate target lesion.
• •5. Known untreated severe valvular heart disease
• •6. Target lesion is located in or supplied by an arterial or venous bypass graft
• •7. History of cardiac allograft transplantation
• •8. Aorto-ostial lesions with an estimated diameter stenosis \>50%
• •9. Severe tortuosity precluding the acquisitions of 2 orthogonal projections of the target vessel with minimal overlap or foreshortening.
• •10. Absolute contraindications or allergy that cannot be pre-medicated, to iodinated contrast or adenosine
• •11. Non-cardiac co-morbidities with a life expectancy less than 1 year
• •12. Currently participating in another trial that is not yet at its primary endpoint. The patient is not allowed to participate in another investigational device or drug study until the trial primary endpoint time point is achieved and may only be enrolled once in the study
• •13. Women of childbearing potential who do not have a negative pregnancy test within 24 hours before the procedure
• •14. Subject belongs to a vulnerable population (per Investigator's judgment) or subject unable to read or write