Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
King's College London
With
Guy's and St Thomas' NHS Foundation Trust
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1\. A diagnosis of HFpEF, defined by the European Society of Cardiology (ESC) criteria, defined as:
1. Symptoms of heart failure (New York Heart Association (NYHA) class II-IV) and
2. Left ventricular ejection fraction ≥ 50% and
3. NT-pro-BNP \> 125 pg/ml in sinus rhythm or \> 365 pg/ml in atrial fibrillation and
4. One or more of the following objective signs of left ventricular diastolic dysfunction:
i. Invasively measured left ventricular end diastolic pressure ≥ 15 mmHg at rest or ≥ 25 mmHg on exercise (directly measured or estimated via pulmonary capillary wedge pressure) ii. Estimated pulmonary artery systolic pressure \> 35mmHg or tricuspid regurgitation velocity \> 2.8 m/s on echocardiography iii. Left atrial volume index \> 34ml/m2 in patient in sinus rhythm or left atrial volume index \> 40ml/m2 in atrial fibrillation iv. Relative left ventricular wall thickness \> 0.42 v. Left ventricular mass index ≥ 95 g/m2 in females or ≥ 115 g/m2 in males vi. Mitral E/E' ratio \> 9
You may not be if
1. Age \<18 years
2. People without capacity to provide informed consent
3. PCI contraindicated or not feasible on coronary angiography or screening CTCA
4. Contraindication to clopidogrel/dual antiplatelet therapy
