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Pain After Proximal Digital Amputation Prevention | Clinical Trials | Clareo Health

TERMINATEDNA

Pain After Proximal Digital Amputation Prevention

NCT04378062•Indiana University

Summary

Finger amputations are common and may be complicated by debilitating nerve pain. This study seeks to determine if nerve pain after digital amputation can be more effectively prevented with either of two new surgical techniques-targeted muscle reinnervation (TMR) or regenerative peripheral nerve interfaces (RPNI)-compared to standard treatment by traction neurectomy (TN).

Detailed Description

Patients who require proximal amputations will have the opportunity to enroll in the study, will be randomized intraoperatively to receiving one of the aforementioned treatments, and will be followed at 3 and 6 month for outcome measures.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients requiring single finger amputations at the level of the proximal interphalangeal joint or proximal (i.e., closer to the body than this joint).
•Patients have the capacity to complete the informed consent process

Exclusion Criteria

•Patients less than 18 years of age, prisoner, or other vulnerable population
•Patients with significant concomitant ipsilateral extremity injuries that would confound study
•Patients requiring emergent, staged (guillotine-type) amputations of any kind

Locations (1)

Eskenazi Hospital

Indianapolis, Indiana, United States

Key Dates

Start Date

March 1, 2020

Primary Completion Date

February 1, 2023

Completion Date

February 1, 2023

Last Updated

August 30, 2023

Enrollment

ACTUAL participants

Conditions

PainAmputation NeuromaAmputation

Interventions

Digital nerve procedure

PROCEDURE

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RECRUITINGPHASE1/PHASE2

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 30, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Pain After Proximal Digital Amputation Prevention

Inclusion Criteria

Exclusion Criteria

Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation.

Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

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