Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

Exclusion Criteria

• •Any individual who meets any of the following criteria will be excluded from participation in this study:
• •American Society of Anesthesiology Physical Classification (ASA) Class V
• •Urgent or emergent surgery
• •Contraindications to administration of Suzetrigine:
• •* Patients who take moderate-to-severe CYP3A inhibitors (such as Ritonavir, Voriconazole, and Clarithromycin)
• •* Patients who take moderate-to-severe CYP3A inducers (such as Phenytoin, Carbamazapine, and Rifabutin)
• •* Patients with moderate to severe hepatic impairment
• •History of substance use disorder or chronic opioid use or alcohol abuse
• •Reoperation
• •Patient refusal or inability to consent
• •Pregnancy