A Study to Evaluate the Safety of THR-149 in Subjects With Diabetic Macular Edema (DME)

Exclusion Criteria

• •Macular edema due to causes other than DME
• •Concurrent disease in the study eye, other than central-involved DME, that could compromise BCVA, require medical or surgical intervention during the study period or could confound interpretation of the results
• •Any condition that could confound the ability to detect a change in central subfield thickness in the study eye
• •Previous confounding treatments / procedures, or their planned / expected use during the study period
• •Presence of neovascularization at the disc (NVD) in the study eye
• •Uncontrolled glaucoma in the study eye
• •Any active ocular / intra-ocular infection or inflammation in either eye
• •Poorly controlled Diabetes Mellitus
• •Uncontrolled hypertension