Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
AstraZeneca
This study will initially treat up to approximately 300 patients with advanced solid tumors at approximately 30 sites, worldwide. The study will be composed of a dose-limiting toxicity (DLT) assessment phase (Part A) and an expansion phase (Part B).
Age
18–110
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
World Health Organization (WHO)/ECOG performance status of 0 or 1
Body weight \>30 kg at enrollment and treatment assignment
At least 1 measurable lesion, not previously irradiated
No prior exposure to immune-mediated therapy (including therapeutic anticancer vaccines)
For patients with oropharyngeal HNSCC HPV status has to be known
You may not be if
Patients with simultaneous primary malignancies or bilateral tumors
Active or prior documented autoimmune or inflammatory disorders
Brain metastases or spinal cord compression
Active infection including tuberculosis, hepatitis B, hepatitis C, or human immunodeficiency virus (HIV; positive HIV 1/2 antibodies)
Has a paraneoplastic syndrome (PNS) of autoimmune nature
HNSCC cohort: Head and neck cancer that does not include unresectable, locally advanced cancer of oral cavity, larynx, oropharynx or hypopharynx. HNSCC of unknown primary are also excluded
NSCLC and SCLC cohort: Mixed SCLC and NSCLC histology
SCLC cohort: Extensive-stage SCLC
Clareo Health | Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors
