High-Dose Statin Combined With Telmisartan vs Amlodipine on Glucose Metabolism in ASCVD Patients With IFG and Hypertension

Exclusion Criteria

• •1. Those who are treated with secondary hypertension or malignant hypertension
• •2. Uncontrollable diabetes with HbA1c ≥ 10%
• •3. Total cholesterol ≥ 300mg/dL
• •4. Fasting LDL-C ≤ 70 mg/dL
• •5. Fasting triglyceride ≥ 500 mg/dL
• •6. History of muscular disease or rhabdomyolysis due to use of statin
• •7. Hypersensitive to statin or ARBs
• •8. Contraindications stated in the SPC of telmisartan or rosuvastatin including the following:
• •* severe renal disease (CrCL \< 30mL/min: Cockcroft-gault formula or estimated GFR (MDRD) \< 30mL/min/1.73m2)
• •* ALT, AST \> 3x ULN or history of active liver disease
• •* CPK \> 3x ULN
• •* hyperkalemia with serum K \> 5.5 mEq/l
• •9. Those who are participating in clinical trials of other investigational products
• •10. Those who cannot discontinue all other treatment for hypertension or hyperlipidemia than the investigational products, and concomitant medications and supplements that can affect the therapeutic effect of hypertension and hyperlipidemia during the trial period
• •11. Other than the above who is deemed to be ineligible to participate in the trial by investigator