Topical Bimatoprost in the Treatment of Migraine

Exclusion Criteria

• •Significant liver or renal dysfunction,
• •On treatment for inflammatory bowel disease, medication over-use for headaches according to the ICHD II criteria,
• •Use of antipsychotics in the past month,
• •Recent (in the past six months) history of alcohol or drug abuse,
• •Allergy to bimatoprost and its compounds,
• •Severe comorbid psychiatric illness,
• •Severe infection,
• •Malignancy,
• •Severe cardiovascular disease,
• •Neurodegenerative disorders,
• •Pregnancy and lactation, and
• •Sexually active women of child bearing age who do not use any method of contraception.