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China HeadAche DIsorders RegiStry | Clinical Trials | Clareo Health

RECRUITING

China HeadAche DIsorders RegiStry

NCT05334927•Beijing Tiantan Hospital

Summary

It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected. The biomarkers, imaging features, cognition, genetic characteristics, ocial and demographic data, medical data, therapeutics used, and outcome of headache-related diseases were studied, and long-term follow-up was planned.

Eligibility

Age

12 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Age ≥ 12 years old,Any gender;
•2. The first onset age of primary headache was less than 50 years old(Age \<65 years at first diagnosis of chronic migraine);
•3. patients with primary headache (migraine, tension headache and other types of primary headache) or primary headache complicated with MOH according to ICHD-3;
•4. Sign the informed consent form.

Exclusion Criteria

•1. According to the ICHD-3 diagnostic criteria, there are still headaches directly related to secondary factors (except drug overuse) at the time of enrollment;
•2. Those who cannot be diagnosed as primary headache or primary headache combined with medication overuse headache according to ICHD-3;
•3. According to DSM-V diagnostic criteria, patients with severe mental diseases (such as schizophrenia, mental disorders associated with mental retardation, etc.);
•4. Patients with severe organic diseases, such as malignant tumors, and the expected survival time is less than 1 year;
•5. Pregnant,planning pregnancy or Lactating women;
•6. Subjects participating in other clinical trials;
•7. Unable to cooperate to complete the follow-up due to geographical or other reasons

Locations (20)

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

Chongqing People's Hospital

Chongqing, Chongqing Municipality, China

Fujian Provincial Hospital

Fuzhou, Fujian, China

The First Affiliated Hospital of Guangxi University of Chinese Medicine

Nanning, Guangxi, China

The First People's Hospital of Zunyi

Zunyi, Guizhou, China

Ruijin-Hainan Hospital Shanghai Jiao Tong University School Of Medicine

Qionghai, Hainan, China

Zhangjiakou First Hospital

Zhangjiakou, Hebei, China

Luohe Central Hospital

Luohe, Henan, China

Luoyang Central Hospital

Luoyang, Henan, China

Key Dates

Start Date

August 29, 2022

Primary Completion Date

December 31, 2031

Completion Date

December 31, 2032

Last Updated

January 15, 2026

Enrollment

10,000

ESTIMATED participants

Conditions

Headache Disorders, PrimaryMigraineNew Daily Persistent HeadacheMedication Overuse HeadacheTension-Type HeadacheTrigeminal Autonomic Cephalalgia

Interventions

Medicine Overuse Headache/New Daily Persistent Headache

BEHAVIORAL

Episodic Migraine and Chronic Migraine

BEHAVIORAL

Patients with other types of primary headache

BEHAVIORAL

Yangxue Qingnao Granules (Pills)

DRUG

Erenumab

BIOLOGICAL

Eptinezumab

BIOLOGICAL

Contacts

Yong Gang Wang, Doctor

CONTACT

15010066622 w100yg@163.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 15, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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China HeadAche DIsorders RegiStry

Inclusion Criteria

Exclusion Criteria

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