Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine

Exclusion Criteria

• •1. Patients with a history of PFO closure or other migraine-related surgical treatments;
• •2. Patients with other severe cardiac or neurological diseases, mental disorders, or psychological conditions;
• •3. Patients with contraindications to closure surgery or MRI scans (e.g., severe infection, coagulation dysfunction, cardiac pacemakers, aneurysm clips, metallic foreign bodies in the eye, non-removable metal dentures, etc.);
• •4. Patients unable to complete migraine symptom assessments or imaging examinations due to other reasons.