The Therapeutic Effect of Transcranial Direct Current Stimulation on Depression in Parkinson's Disease

Inclusion Criteria

• •1. In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.
• •2. The participant or, when applicable, the participant's legally acceptable representative signs and dates a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures.
• •3. Suffers from Parkinson's disease fulfill the Parkinson's Disease Society Brain Bank clinical criteria with insidious 2 or more PD symptoms (bradykinesia, tremor, or rigidity).
• •4. Suffers from "DSM-IV major depressive disorder, single episode" or "DSM-IV major depressive disorder, recurrent" according to Diagnostic \& Statistical Manual of Mental Disorders, 4th Edition - Text Revision (DSM-IV-TR) criteria.
• •5. Reported duration of the current episode is ≥4 weeks and has not been treated with antidepressants.
• •6. Has a Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥20 at the screening (baseline) visit.
• •7. Is a man or woman aged 18 to 75 years, inclusive.