Apathy in Parkinson Disease TMS Study

Exclusion Criteria

• •Inability to provide informed consent.
• •Inability to perform effort task (determined during the titration session).
• •Presence of dementia (Montreal Cognitive Assessment (MoCA) score \< 21).
• •History of epilepsy or brain surgery.
• •Severe tremor or dyskinesia that would interfere with EEG (determined by the PI).
• •Patients with clinically significant medical or neurological conditions which may be an alternative cause of parkinsonism such as repeated brain injury, anti-dopaminergic medications, anoxic brain injury, or significant basal ganglia strokes.
• •Presence of other known central nervous system disease that may interfere with performance or interpretation of EEG or TMS.
• •Presence of any implanted metal devices including, but not limited to, pacemakers, deep brain stimulators, vagal nerve stimulators, bladder stimulators, or cochlear implants.
• •Presence of medical contraindications to TMS such as implanted stimulators, history of mania or bipolar disorder, history of epilepsy.