Hypofractionated Radiotherapy (16/2) for the Palliation of Complicated Bone Metastases in Patients With KPS

Inclusion Criteria

• •1. Histologically or cytologically proven malignancy.
• •2. Patients aged 18 and above.
• •3. Advanced cancer patients with at least one complicated bone metastasis. A complicated bone metastasis will be operationally defined as a bone metastasis that has an accompanying: soft tissue mass or extraosseous component penetrating the normal cortical boundary; neuropathic pain; post surgical intervention for bone fixation; impending fracture or high fracture risk in weight bearing long bone as defined by Harrington's criteria but not surgical candidate: lytic bone lesion involving more than ½ the diameter of the bone cortex , greater than 2.5 cm in greatest diameter, or in the intertrochanteric line (29).
• •4. Patients with Karnofsky Performance Status (KPS) 30-60 at the time of baseline evaluation.
• •5. Patients who are planned to receive radiation treatment to the complicated site(s) being followed for study.
• •6. Patients who had surgery for complicated bone metastases.
• •7. Patients who are currently taking any systemic therapy (i.e. chemotherapy, hormone therapy, or bone modifying agents) or planning to begin systemic therapy within two weeks of treatment will be allowed to participate in the study; study personnel will note any use of systemic therapy in the study records.
• •8. Patients who are able to provide a worst pain score at the complicated site(s) being followed for study.
• •9. Patients who are able and willing to fill out a daily diary.
• •10. Patients who are able to provide informed consent prior to being enrolled to the study.