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Simulation-Free, Single-Fraction Palliative Radiation Therapy for Treatment of Bone Metastases | Clinical Trials | Clareo Health

RECRUITINGNA

Simulation-Free, Single-Fraction Palliative Radiation Therapy for Treatment of Bone Metastases

A Feasibility Study of Simulation-Free, Single-Fraction Palliative Radiation Therapy for Treatment of Bone Metastases (SIM-FREE RT)

NCT07202273•University of Utah

View on ClinicalTrials.gov

Summary

The goal of this study is to provide proof that patients can be treated with simulation-free, single-fraction palliative radiation therapy with a single in-person visit.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Participant aged ≥ 18 years.
•Diagnosis of any cancer with one to two painful and treatable metastatic bone lesions.
•Bone metastases are causing pain or instability in the opinion of the treating investigator.
•Amenable to single fraction radiation therapy per the discretion of the treating physician.
•CT collected within 60 days of registration with adequate visualization of target site as determined by the treating investigator.
•ECOG Performance Status ≤ 2.
•Participants must adhere to the following sex and contraceptive/barrier requirements:
•* If participant is of childbearing potential, they must have a negative pregnancy test ≤ 14 days before the planned date of radiation therapy. This may be completed on the day of radiation if results from the pregnancy test are available for review before treatment.
•* For participants of non-child bearing potential: The post-menopausal status will be defined as having been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:
•* \< 50 years of age:
+8 more criteria

Exclusion Criteria

•Evidence of spinal cord compression caused by the bone metastases to be treated.
•Any other condition that would, in the Investigator's judgment, contraindicate the participant's participation in the clinical study due to safety concerns or compliance with clinical study procedures.
•Medical, psychiatric, cognitive, or other conditions that may compromise the participant's ability to understand the participant information, give informed consent, comply with the study protocol or complete the study.
•Participants taking prohibited medications as described in Section 6.7.1.

Locations (1)

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, United States

Key Dates

Start Date

November 3, 2025

Primary Completion Date

October 1, 2027

Completion Date

October 1, 2028

Last Updated

November 5, 2025

Enrollment

ESTIMATED participants

Conditions

Bone Metastases

Interventions

simulation-free, single-fraction palliative radiation therapy

RADIATION

Contacts

Rachel Kingford

CONTACT

8015850115 Rachel.kingsford@hci.utah.edu

Shane Lloyd, MD

CONTACT

8015850255 Shane.lloyd@hci.utah.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 5, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Simulation-Free, Single-Fraction Palliative Radiation Therapy for Treatment of Bone Metastases

Inclusion Criteria

Exclusion Criteria

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