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Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect | Clinical Trials | Clareo Health

COMPLETEDPHASE1

Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect

Phase I Study of Human Umbilical Cord Mesenchymal Stem Cell Implantation in the Treatment of Articular Cartilage Defect of Knee

NCT02291926•Shenzhen Hornetcorn Bio-technology Company, LTD

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.

Detailed Description

Human articular cartilage has limited repair potential.Cell-based strategies have explored chondrocytes and mesenchymal stem cells (MSCs) with extensive basic science and preclinical studies.However the concept of autologous chondrocyte implantation is not ideal,so the focus in cartilage repair is shifting toward mesenchymal stem cells. To investigate the effects of hUC-MSC treatment for articular cartilage defects, 20 patients will be enrolled and receive 4 times of hUC-MSC transplantation.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients must consent in writing to participate in the study by signing and dating an informed consent document
•Healthy patients with no major history of illness
•Patients must have a diagnosis of osteoarthritis by radiographic criteria of Kellgren and Lawrence grade 2-4
•Patients who needs invasive interventions of arthroplasty due to no response from existing pain medication
•Patients must have had more than Grade 4 (0\~10 point numeric scale) pain at least for four months
•Patient's damaged cartilage area should be in the range of 2-6cm2

Exclusion Criteria

•Pregnant women or lactating mothers
•Patients who have received any anti-inflammatory drugs including herb-drug within 14 days
•Patients who received any drug by intra-articular injection for treatment within 2 months prior to this enrollment
•Patients with positive human immunodeficiency (HIV) at screening indicative of current of pass infection
•Impaired liver function, abnormal blood coagulation, combine other tumor or special condition
•Patients who had participated in other clinical trials within three months prior to this study

Locations (1)

The Fifth Affiliated Hospital Immunotherapy center

Guangzhou, Guangdong, China

Key Dates

Start Date

December 1, 2014

Primary Completion Date

July 1, 2016

Completion Date

December 1, 2016

Last Updated

May 10, 2017

Enrollment

ACTUAL participants

Conditions

Cartilage DiseasesOsteoarthritis

Interventions

Human umbilical cord mesenchymal stem cells

BIOLOGICAL

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

NCT07153471

Osteoarthritis

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RECRUITINGPHASE1

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

NCT07351968

Moderate Pain in Knee OsteoarthritisSevere Pain in Knee Osteoarthritis

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 10, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect

Inclusion Criteria

Exclusion Criteria

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

General vs Spinal in Total Joint Arthroplasty (TJA)

CBD for Pain Following Orthopedic Shoulder Surgery

PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults

A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression