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General vs Spinal in Total Joint Arthroplasty (TJA) | Clinical Trials | Clareo Health

RECRUITINGNA

General vs Spinal in Total Joint Arthroplasty (TJA)

General Versus Spinal Anesthesia for Total Joint Arthroplasty: A Prospective Randomized Trial

NCT06747494•University of Miami

Summary

The purpose of this research is to compare post-operative outcomes from patients undergoing TJA. The study team wants to learn about outcomes like length of hospital stay, post-operative pain scores, post-operative nausea, deep and superficial surgical site infection, periprosthetic fracture (a broken bone that occurs around an orthopaedic implant), implant dislocation, readmission rates, and revision rates.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients undergoing a primary total hip or knee arthroplasty
•Subjects must be capable of providing informed consent
•English or Spanish speaking

Exclusion Criteria

•Patients with contraindications for spinal anesthesia such as:
•Prior lumbar surgery with hardware insertion
•Elevated intracranial pressure
•Infection at the site of the procedure
•Thrombocytopenia or coagulopathy
•Severe mitral and aortic stenosis and left ventricular outflow obstruction
•Severe spine pathology (spinal stenosis, spondylolisthesis, spondylosis) with radiculopathy and/or neurogenic claudication
•Preexisting neurological disease
•Patients with contraindications for general anesthesia such as:
•Congestive heart failure
+4 more criteria

Locations (1)

University of Miami

Miami, Florida, United States

Key Dates

Start Date

February 1, 2025

Primary Completion Date

March 1, 2030

Completion Date

March 1, 2030

Last Updated

March 18, 2026

Enrollment

2,396

ESTIMATED participants

Conditions

Knee OsteoarthritisHip Osteoarthritis

Interventions

General Anesthesia

PROCEDURE

Spinal Anesthesia

PROCEDURE

Contacts

Victor H Hernandez, MD

CONTACT

305-689-5195 vhh1@med.miami.edu

Antonio M Fernandez-Perez, MS

CONTACT

305-689-5195 axf2089@miami.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 18, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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General vs Spinal in Total Joint Arthroplasty (TJA)

Inclusion Criteria

Exclusion Criteria

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

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