CBD for Pain Following Orthopedic Shoulder Surgery

Exclusion Criteria

• •Under the age of 18 years old
• •History of revision shoulder arthroplasty
• •History of liver disease or impairment
• •Are currently taking valproate or clobazam
• •Are currently taking a moderate/strong CYP3A4 or CYP2C19 inhibitor
• •Are currently taking a strong CYP3A4 or CYP2C19 inducer
• •Are currently taking narcotics
• •History of substance/alcohol abuse
• •Those currently or previously under the care of a pain management specialist
• •History of marijuana/cannabidiol (not including topical) regular use within the past 6 months
• •Allergy related to cannabidiol
• •Allergy related to sesame seeds
• •Pregnancy (As part of standard of care, all female participants will be administered a urine pregnancy test prior to surgery. A negative test result is required to participate in the study.)
• •If you are taking any medications with known risks for suicidal behavior and ideation
• •If you have a diagnosed psychiatric disorder
• •If you are untreated for a diagnosed sleeping disorder
• •If you are actively breastfeeding
• •Patients currently taking central nervous system (CNS) depressants
• •Patients currently taking other drugs with known hepatotoxicity
• •Vulnerable populations.
• •Patients taking concomitant medications which are substrate of uridine 5'-diphospho-glucuronosyltransferase 1-9 (UGT1A9), uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and P-gp will be monitored for potential adverse events based on the Epidiolex® label for the concomitant medication being used.