A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

Exclusion Criteria

• •1. History of other diseases that may involve the target joint;
• •2. History of major trauma or surgery of knee joint and hip joint in the past year;
• •3. Plan to undergo surgical procedure during the study;
• •4. Most or complete loss of mobility;
• •5. There are other diseases that may confuse the assessment of osteoarthritis pain;
• •6. There is a neuropsychiatric disease, and the investigator's assessment may affect the evaluation of osteoarthritis (OA) or self-score;
• •7. There are serious or poorly controlled concomitant diseases;
• •8. Those who have a clear history of peptic ulcer, bleeding, perforation or obstruction within 1 year before screening, and have been clinically diagnosed;
• •9. Those who require drug treatment or surgical intervention;
• •10. History of malignant tumors within 5 years before screening;
• •11. Have a history of drug abuse, drug abuse and/or alcoholism within 2 years before screening.