Two phosphAte taRGets in End-stage Renal Disease Trial (TARGET)

Exclusion Criteria

• •1. Patient is booked (with a known surgical date) for a live donor kidney transplant in the next 26 weeks
• •2. Planned switch to a dialysis schedule that involves \> 16 hours per week of therapy within the next 26 weeks.
• •3. Planned switch to peritoneal dialysis within the next 26 weeks
• •4. Pregnancy
• •5. Albumin-corrected serum calcium \> 2.60 mmol/L in the past year requiring reduction of the calcium carbonate dose
• •6. History of calciphylaxis
• •7. Attending nephrologist believes that an otherwise eligible patient is mandated- on clinical grounds- to have a P value that is targeted to \< 1.50 mmol/L or \> 2.00 mmol/L
• •8. Attending nephrologist believes an otherwise eligible patient is not a candidate for escalation of the current calcium dose
• •9. Co-enrollment in a clinical trial where the intervention is deemed to interfere with the adherence, safety or efficacy of the intervention provided herein