A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China

Exclusion Criteria

• •History or plan of kidney transplantation
• •History or plan of parathyroid intervention 6 months before signing the ICF
• •Serum calcium \< 1.9 mmol/L (7.6 mg/dL) or \> 2.75 mmol/L (11 mg/dL) at screening
• •Serum intact parathyroid hormone \> 127 pmol/L (1200 pg/mL) at screening
• •Presence of clinically significant gastrointestinal (GI) disorder
• •History of gastrectomy or duodenectomy, or GI surgery within 3 months before signing the ICF
• •Known allergic to any ingredient of AP301, or known history of severe allergies leading to emergency medical care
• •Female who are breastfeeding