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Chronology of Occult and Gross Coagulopathy in Burn Patients | Clinical Trials | Clareo Health

COMPLETED

Chronology of Occult and Gross Coagulopathy in Burn Patients

Determining the Chronology of Occult and Gross Coagulopathy in Thermally Injured Patients: A Systems Biology Approach

NCT01638481•Medstar Health Research Institute

Summary

The purpose of the study is to identify the inflammatory and coagulation pathways and mechanisms that are activated immediately following burn injury, and how they affect outcomes in terms of organ failure and death. This study also addresses the limitation of current tests (PT, PTT, and platelet counts) employed to identify coagulation disturbances in severely injured patients both in a comprehensive and rapid manner.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients, male or female, \> or = 18 years of age, who arrive at Burn/Trauma Center with anticipated admission to The Burn Center within 4 hours of injury, with a thermal burn injury due to flash, flame, contact with hot object or liquid.

Exclusion Criteria

•Patients suffering concomitant trauma that are in hemorrhagic shock. Patients with a preexisting history of coagulopathy, or currently taking anti-coagulants. Children and pregnant women. Patients with chemical or electrical injury. Patients who do not fluently speak either English or Spanish.

Locations (1)

MedStar Washington Hospital Center

Washington D.C., District of Columbia, United States

Key Dates

Start Date

July 1, 2012

Primary Completion Date

March 1, 2017

Completion Date

June 1, 2021

Last Updated

February 16, 2022

Enrollment

158

ACTUAL participants

Conditions

Thermal Burns

A Safety, Tolerability and Pharmacokinetic Study of cP12 in Adults With Up To 10% Total Body Surface Area Burns

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Thermal Burns

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COMPLETEDPHASE4

Continuous Lidocaine Infusion for Management of Perioperative Burn Pain

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Thermal Burns

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UNKNOWNPHASE1

Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

NCT02169362

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 16, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Chronology of Occult and Gross Coagulopathy in Burn Patients

Inclusion Criteria

Exclusion Criteria

A Safety, Tolerability and Pharmacokinetic Study of cP12 in Adults With Up To 10% Total Body Surface Area Burns

Continuous Lidocaine Infusion for Management of Perioperative Burn Pain

Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

The Effects of Hyperbaric Oxygen Therapy (HBOT) on Acute Thermal Burns