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The Effects of Hyperbaric Oxygen Therapy on Acute Thermal Burns
The blinded RCTstudy aims to: * Determine the effects of HBOT on burns conversion for patients who have fresh thermal burns injury using the LDI. * Objectively determine the proportion of burns conversion in areas of partial thickness burns for early thermal burns injury in both arms of the RCT. * Study the effects of HBOT on immunological markers IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α and TGF-β ( comparison between both arms and 2 assessment points). * Study the effect of HBOT on haematological markers including procalcitonin ,albumin, lymphocyte counts, neutrophil count, and macrophage count. * Study the effects of HBOT on histology specimens in quantifying P53 protein, leukocyte and macrophage infiltration, burns depth assessment and vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) . * Study the effects of HBOT on bacteriology of tissue culture in areas of deep dermal burns.
Age
21 - 60 years
Sex
ALL
Healthy Volunteers
No
Singapore General Hospital
Singapore, Singapore
Start Date
January 1, 2009
Primary Completion Date
December 1, 2010
Last Updated
January 16, 2009
80
ESTIMATED participants
Hyperbaric Oxygen Therapy
PROCEDURE
Standard care
OTHER
Lead Sponsor
Singapore General Hospital
Data Source & Attribution
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