Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

Exclusion Criteria

• •Conductive electrical, friction or chemical burns
• •Burns to the digits, head, genitalia, palms of hands, soles of feet, and face that are the only possible sites for treatment (subjects with burns elsewhere in addition to these sites may be enrolled in the study)
• •Burns that pose a risk to digits or limbs
• •Subjects who have gone into hemorrhagic shock following burn injury
• •Subject was medically treated for insulin-dependent or non-insulin-dependent diabetes mellitus prior to burn injury per subject medical history
• •Venous or arterial vascular disorder directly affecting a designated test area
• •Known immune deficiency disorder, either congenital or acquired
• •Chronically malnourished as determined clinically by the investigator. (Investigators are responsible for determining if subjects are chronically malnourished during the screening process. Investigators should take into consideration the following parameters: medical history and physical appearance, the subject's body mass index, and any significant laboratory findings)
• •Severe respiratory problems or concurrent head trauma at hospital admission, including inhalation injury requiring ventilator support
• •Any chronic condition requiring the use of systemic corticosteroids 30 days prior to study entry and anytime during the course of the study
• •Use of COX-1 and/or COX-2 inhibitors within 48 hours prior to treatment. Subjects must refrain from use of NSAIDs for five days after Visit 2.
• •Any other acute or chronic concurrent medical condition(s) that, in the investigator's opinion, are a contraindication to study participation or limit the subject's life expectancy to \< 6 months
• •Known or suspected hypersensitivity to Recothrom®
• •Concurrent participation in another clinical trial in which an investigational agent is used. (Subjects must not have been enrolled in another clinical trial within 30 days of enrolling in this trial)
• •Females who are pregnant or nursing or intend to become pregnant during the duration of the study
• •Burn wounds that occur over joints
• •Known allergies to silver, adhesive products or silicone.
• •Subjects with the following abnormal laboratory test levels:
• •Stage 4 or greater chronic kidney disease (eGFR \< 30 mL/min
• •Hemoglobin \< 10 g/dl
• •Thrombocytopenia \< 100,000 platelets/µl.
• •Serum albumin level \< 2.5 g/dl or \> 30 g/dl at time of screening
• •Liver function\*:
• •AST- Males and Females, \>2.5 ULN
• •ALT- Males and Females, \>2.5 ULN
• •Alkaline Phosphatase- Males and Females: \>2.0 ULN
• •Total bilirubin- Males and Females \>2.0 ULN