SAS115359: A 6-month Study to Assess the Safety and Benefit of Inhaled Fluticasone Propionate/Salmeterol Combination Compared With Inhaled Fluticasone Propionate in the Treatment of Adolescents and Adults (12 Years of Age and Older) With Asthma.

Exclusion Criteria

• •History of life threatening asthma defined for this protocol as asthma episode that required intubation and/or was associated with hypercapnea requiring non-invasive ventilatory support
• •Concurrent respiratory disease other than asthma
• •Current evidence of, or ever been told by a physician that they have chronic bronchitis, emphysema, or chronic obstructive pulmonary disease.
• •Exercise induced asthma (as the only asthma-related diagnosis) not requiring daily asthma control medicine
• •Presence of a bacterial or viral respiratory infection that is not resolved at randomization
• •An asthma exacerbation requiring systemic corticosteriods within 4 weeks of randomization or more than 4 separate exacerbations in the 12 months preceding randomization
• •More than 2 hospitalizations for treatment of asthma in the 12 months preceding randomization
• •Subject must not meet unstable asthma severity criteria as listed in the protocol
• •Potent cytochrome P450 3A4 (CYP3A4) inhibitors within the last 4 weeks (e.g., ritonavir, ketoconazole, itraconzole)
• •Pregnancy, breast-feeding or planned pregnancy during the study
• •A Child in Care (CiC) is a child who has been placed under the control or protection of an agency, organisation, institution or entity by the courts, the government or a government body, acting in accordance with powers conferred on them by law or regulation.