Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of Age

Exclusion Criteria

• •Patient receiving immunosuppressant medication (e.g. cyclosporine, MMF, etc) other than oral/topical steroids, for any medical condition
• •Current diagnosis of heart failure (NYHA Class II-IV) or history of cardiomyopathy or obstructive valvular disease
• •msSBP ≥ 25% above the 95th percentile
• •Second or third degree heart block without a pacemaker
• •AST/SGOT or ALT/SGPT \>3 times the upper limit of the reference range
• •Total bilirubin \> 2 times the upper limit of the reference range
• •Creatinine clearance \< 30 mL/min/1.73m² (calculated using Modified Schwartz formula to estimate glomerular filtration rate \[GFR\]), based on the serum creatinine concentration obtained at the screening visit)
• •WBC count \< 3000/mm³