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A Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia

An Open-label Multi-center Safety and Tolerability Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia & Healthy Volunteers

NCT01055561•Chengdu University of Traditional Chinese Medicine

View on ClinicalTrials.gov

Summary

The purpose of the study is to evaluate the safety and tolerability of acupuncture for patients with BPSD \& healthy volunteers.

Detailed Description

This open label study is designed to evaluate the safety and tolerability of acupuncture as a intervention for patients with Behavioral and Psychological Symptoms of Dementia (BPSD)\& healthy volunteers,and this study will enroll a total of 30(15 patients,15healthy volunteers) patients who are suffered from BPSD or healthy volunteers.The patients who have to be suitable for the standard of inclusion criteria will be included,and who have one condition of the exclusion criteria will be excluded,and so do the healthy volunteers.For each enrolled participant will obtain a baseline psychiatric and medical assessment, results of the Mini-Mental Status-Evaluation (MMSE),Behavioral Pathology in Alzheimer's Disease Rating Scale(BEHAVE-AD),Activity of Daily Living Scale(ADL)and other basic information prior to beginning acupuncture.For each participant will get acupuncture which once a day for 7 days running. During the trial the Questionnaire of Acupuncture-related Events have to be evaluated every day, and at the end of the intervention,all of the MMSE,BEHAV-AD,ADL and Treatment Emergent Symptom Scale (TESS)will be investigated.

Eligibility

Age

60 - 85 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•The eligibility criteria of the patients arm:
•1. patients who aged 60 to 85(inclusive) years
•2. The MMSE score of patients must be between 5 to 26
•3. Patients with diagnosis of Alzheimer's Disease according to DSM-Ⅳ（Diagnostic and Statistical Manual of Mental Disorders Fourth Edition)
•4. patients have one or more "target symptoms" of Behavioral and Psychological Symptoms of Dementia(BPSD) on the behavioral psychology in Alzheimer's disease rating scale (BEHAVE-AD),and the "target symptoms " of BEHAVE-AD have to have occurred nearly daily during the previous week or at least intermittently for 4 weeks
•5. Patients (or a legally acceptable representative)have signed the informed consent form
•1. Healthy volunteers aged 60 to 85(inclusive) years who have provided written informed consent
•2. MMSE\> or =27
•3. Have relative better health condition who do not suffered from severe system disease (e.g.,cardiovascular, hepatorenal, hematopoietic system) or infectious disease

Exclusion Criteria

•1. Received a diagnosis of a primary psychotic disorder (e.g.schizophrenia，bipolar disorder, severe or recurrent depression),other dementia such as vascular dementia,complex dementia or Lewy-body dementia,or psychosis,agitation, or aggression that could be better accounted for by another medical condition, or substance abuse
•2. Had severe system disease (e.g., cardiovascular, hepatorenal, hematopoietic system) or infectious disease
•3. Received medication (e.g.,benzodiazepines, antipsychotics, or anticholinergics)which could treat BPSD within 2 weeks prior to the first acupuncture of the study
•4. Participated in any clinical trial of drug within 4 weeks prior to the study
•5. History of taking acupuncture
•The eligibility criteria of the healthy volunteers arm:
•1. History of significant neurological (including history of seizures,EEG abnormalities or dementia) or psychotic disorder (e.g.schizophrenia，bipolar disorder, severe or recurrent depression)
•2. History of drug or alcohol abuse
•3. History of taking medication that may be impair the function of cognition or psychotic behavior within 4 weeks before the study
•4. Participated in any clinical trial of drug within 4 weeks prior to the study
+1 more criteria

Locations (1)

Yong Tang

Chengdu, Sichuan, China

Key Dates

Start Date

January 1, 2010

Primary Completion Date

February 1, 2011

Completion Date

March 1, 2011

Last Updated

May 30, 2016

Enrollment

ACTUAL participants

Conditions

Alzheimer's DiseaseDementia

Interventions

Acupuncture

OTHER

ACP-204 in Adults With Alzheimer's Disease Psychosis

NCT06159673

Alzheimer's Disease Psychosis

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RECRUITING

Lombard Cohort of Brain Health Services

NCT07457138

Subjective Cognitive Decline (SCD)Functional Cognitive Disorder+2 more

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RECRUITING

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 30, 2016Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia

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