Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome

Exclusion Criteria

• •Evidence of neurological or other physical illness that could produce cognitive deterioration; volunteers with a history of TIAs, carotid bruits, or lacunes on MRI scan will be excluded
• •Parkinson's Disease
• •History of myocardial infarction within the previous year or unstable cardiac disease
• •Uncontrolled hypertension (systolic BP \> 170 or diastolic BP \> 100), history of significant liver disease, clinically significant pulmonary disease, diabetes, or cancer
• •Major psychiatric disorders, such as bipolar disorder or schizophrenia
• •Medicines that could influence psychometric test results
• •Use of any of the following drugs: centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, benzodiazepines, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anti-convulsants, or warfarin
• •Current diagnosis or history of alcoholism or drug dependence
• •Evidence of untreated depression or untreated anxiety
• •Use of any investigational drugs within the previous month or longer, depending on drug half-life
• •Contraindication for MRI scan (e.g., metal in body, claustrophobia)
• •Diagnosis of possible or probable AD or any other dementia (e.g., vascular, Lewy body, frontotemporal) or MCI
• •Mosaic form of Down syndrome
• •History of clinically significant neurological disorder or disease and Psychiatric diagnosis or treatment within 3 months prior to screening