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Carotene and Retinol Efficacy Trial | Clinical Trials | Clareo Health

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COMPLETEDPhase 4NCT00712647

Carotene and Retinol Efficacy Trial

The Carotene and Retinol Efficacy Trial (CARET) was a randomized, double-blind, placebo-controlled trial of the cancer prevention efficacy and safety of a daily combination of 30 mg of beta-carotene a...

Lead sponsor: Fred Hutchinson Cancer Center•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Fred Hutchinson Cancer Center

Collaborators

National Cancer Institute (NCI)

Age

45 - 69 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Asbestos-exposed men who were:
•* current smokers or quit within 15 years prior to enrollment
•* had first exposure to asbestos on the job at least 15 years prior to enrollment
•* had chest X-ray positive for changes compatible with asbestos exposure according to ILO criteria; or had been employed in a protocol-defined high-risk trade for at least 5 years, at least 10 years prior to enrollment.
•Heavy Smokers, men and women:
•* cigarette smoking history of 20+ pack-years
•* either current smokers or had quit within previous 6 years

Exclusion Criteria

•Pre-menopausal women
•History or cirrhosis or hepatitis within 12 months prior to enrollment
•Taking \> 5500 IU daily vitamin A supplement
•Taking any beta-carotene supplement
•History of cancer within 5 years prior to enrollment
•SGOT \> than 2.5X upper limit of normal, or alkaline phosphatase \> 1.5X upper limit of normal
•taking less than 50% of study vitamins during the enrollment period between the First and Second Visits.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 26, 2012Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment18,314

Start dateMay 1985

Last updatedSep 26, 2012

Condition

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 26, 2012Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions