Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols

Background: -Immunotherapy is a promising approach to the treatment of cancer. CIO investigators are studying immunotherapy for the treatment of diverse malignant and premalignant conditions. These studies require the collection of biospecimens for research purposes. Objectives: * To collect and bank blood, apheresis products, tumor, body fluids, and other biospecimens from patients with cancer or a premalignant disease or at risk of cancer from an immunodeficiency. * To collect and bank biospecimens as directed by companion CIO immunotherapy clinical trial protocols. * To conduct nucleic acid, protein, and immunological and biological research studies on samples collected. Eligibility: -Patients must be 18 years of age or older with a diagnosis of cancer or a premalignant condition or an immunodeficiency that increases the risk of being diagnosed with a cancer or premalignant condition. Design: * Up to 500 subjects will be enrolled. * Patients will undergo sampling of blood, apheresis products, tumor, effusions, ascites, urine, bone marrow, serum, plasma, skin, mucosa, or other tissues for banking and laboratory studies. * No investigational or experimental therapy will be given as part of this protocol. * Re-enrollment will be allowed for a small number of participants.