Lead Sponsor

Medical University of Vienna

Age

18 - 35 years

Sex

ALL

Healthy Volunteers

Yes

•24 subjects aged between 18 and 35 years, nonsmokers (since at least 2 years)
•24 subjects aged between 18 and 35 years, smokers (at least 10 cigarettes/day since 2 years)
•Body mass index between 15th and 85th percentile
•Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
•Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
•Normal ophthalmic findings, ametropy \< 3 dpt.

•Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
•Treatment in the previous 3 weeks with any drug
•Symptoms of a clinically relevant illness in the 3 weeks before the first study day
•History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of study drugs
•Blood donation during the previous 3 weeks
•Ametropy \>= 3 dpt

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