Aerosolized Liposomal Camptothecin in Patients With Metastatic or Recurrent Cancer of the Endometrium or the Lung

Inclusion Criteria

• •For Endometrial:
• •All patients, 18 years of age or older, with metastatic and/or recurrent endometrial cancer or with mixed mesenchymal malignant tumors whose epithelial component is recurring, who have failed standard chemotherapy or hormonal regimens for their disease or who refuse recommended standard chemotherapy are eligible.
• •Patients must have a life expectancy of at least 12 weeks.
• •Patients much have a Zubrod performance status of 0-2.
• •Patients must sign an informed consent.
• •Patients should have adequate bone marrow function defined by an absolute peripheral granulocyte count of \>= 1,500 or cells/mm³ and platelet count \> 100,000/mm³ and absence of a regular red blood cell transfusion requirement.
• •Patients should have adequate hepatic function with a total bilirubin \< 2 mg/dl and SGOT or SGPT \< two times the upper limit of normal, and adequate renal function as defined by a serum creatinine \<= 1.5 x upper limit of normal.
• •Patients must not have a known symptomatic respiratory disease other than cancer, and must have a pulmonary function test equal to \>= 50% FEV1, \>= 50% FEV1/FVC, \>= 50% TLC, and \>= 50% DLCO of predicted values.
• •All patients, 18 years of age or older, with stage 3b, 4, or recurrent, nonresectable, non-small-cell lung carcinoma are eligible.
• •Patients must have a life expectancy of at least 12 weeks.
• •Patients must have a Zubrod performance status of 0-2.
• •Patients must sign an informed consent.
• •Patients should have adequate hepatic function with a total bilirubin \< 2 mg/dl and SGOT or SGPT \< two times the upper limit of normal, and adequate renal function as defined by a serum creatinine \<= 1.5 x upper limit of normal.
• •Patients must not have a known symptomatic respiratory disease other than cancer, and must have a pulmonary function test equal to \>= 50% FEV1, \>= 50% FEV1/FVC, \>= 50% TLC, and \>= 50% DLCO of predicted values.