Avastin and Tarceva for Locally Advanced or Metastatic Non-Squamous Non-Small-Cell Lung Cancer

Exclusion Criteria

• •Patient has not received prior chemotherapeutic regimens for advanced disease.
• •Patient has received prior biologic therapy targeting epidermal growth factor receptor (EGFR) and/or Vascular endothelial growth factor (VEGF).
• •Patient has received radiation therapy within the past 3 weeks.
• •Patient has signs or symptoms of acute infection requiring systemic therapy.
• •Patient exhibits confusion, disorientation, or has a history of major psychiatric illness that may impair patient's understanding of the informed consent.
• •Patient requires total parenteral nutrition with lipids.
• •Patient has a history of uncontrolled heart disease and/or uncontrolled hypertension (\> 150/100 mmHg).
• •Because of the possible teratogenic effect, pregnant women and women who are currently breast-feeding may not participate in this study. - All women of childbearing potential must have a negative pregnancy test within 24 hours prior to enrolling in the study.
• •Serious infection or other intercurrent illness requiring immediate therapy.
• •Clinical/imaging evidence of Central Nervous System (CNS) malignancy or with recently treated CNS malignancy, as well as those experiencing recent cerebrovascular accident (CVA), or other CNS bleeding.
• •Pediatric patients in whom open growth plates would be expected.
• •Urine protein qualitative value of \> 30 in urinalysis or \> +1 in proteinuria testing by dipstick.
• •Patient has a clinical history of coagulopathy or thrombosis.
• •Patient is currently receiving or intending to receive anti-coagulants.
• •Patient has had a recent myocardial infarction (still inside the healing period). Note: a six-month window is optimal.
• •Patient is recovering from recent major surgery (e.g., less than 2 weeks since surgery) or is anticipating major surgery.
• •Patient has a clinical history of hemoptysis or hematemesis.
• •Patient may not have percutaneous endoscopic gastrostomy (PEG) or gastrostomy (G) tube.