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No longer availableIndividual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral SclerosisThe drug for this submission is Hope Biosciences' autologous, adipose-derived culture-expanded mesenchymal stem cells (HB-adMSCs) for the treatment of a single patient with…NCT04514952Houston, Texas RecruitingA Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)This study investigates whether an individualized physiotherapy program, tailored to each patient's specific motor deficits, can better support physical function compared with…NCT07341984Sankt Gallen UnknownClinical Trial on the Use of Cell Therapy in the Treatment of Patients With Amyotrophic Lateral SclerosisOur working hypothesis is that the injection of autologous bone marrow mononuclear cells (BMNC) has a positive effect on the natural loss of motor units and on the increase in the…NCT04849065Murcia UnknownThe Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS)There is currently no effective treatment in ALS.NCT04140136Kuala Lumpur RecruitingMotor Neurone Disease - Systematic Multi-Arm Adaptive Randomised TrialMND-SMART is investigating whether selected drugs can slow down the progression of motor neuron disease (MND) and improve survival.NCT04302870Portadown, County Armagh and 21 others CompletedAcoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS)This study proposes to identify acoustic and perceptual markers related to upper motor neuron (UMN) degeneration and lower motor neuron (LMN) degeneration in the dysarthria of…NCT03560661Paris Active not recruitingCOMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With ParalysisThe Synchron motor neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent…NCT05035823Buffalo, New York and 2 others CompletedSupported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral AclerosisThe purpose of this study is to find out if supervised exercise training using a treadmill with partial weight support is safe and has an impact on gait and function of persons…NCT00956488Charlotte, North Carolina Not yet recruitingA Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS PatientsFIH, Phase 1/2, multi-centre, randomised, double-blind, placebo controlled study with an optional open-label dosing extension to assess the safety, tolerability, efficacy, and…NCT06513546 CompletedMIROCALS: Modifying Immune Response and OutComes in ALSMIROCALS is a phase II study of ld-IL-2 as a therapeutic agent for ALS.NCT03039673Lille and 16 others CompletedThe Effect of GCSF in the Treatment of ALS PatientsThe aim of this study is to evaluate the effect off Granulocyte Colony Stimulating Factor (GCSF) in the treatment of Amyotrophic Lateral Sclerosis (ALS) patients.NCT01825551Tehran, Tehran Province TerminatedA Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.The COMMEND Study will assess the safety and effectiveness of FLX-787 in men and women with Motor Neuron Disease \[including Amyotrophic Lateral Sclerosis (ALS), Primary Lateral…NCT03196375Scottsdale, Arizona and 34 others CompletedRespiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)Dysphagia (swallow impairment), dystussia (cough impairment) and respiratory impairment are hallmark features of amyotrophic lateral sclerosis (ALS).NCT02710110Gainesville, Florida RecruitingEffects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their FamiliesAmyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is two to three years.NCT05744310Bodø, Nordland and 8 others CompletedSingle & Multiple Ascending Dose Study of SAR443820 in Healthy Adult ParticipantsThis is a Phase 1, single-center study conducted in 2 parts: Part 1a, single ascending dose (SAD-TDU16519): Double-blind, randomized, placebo-controlled sequential ascending…NCT05795907Saint Paul, Minnesota CompletedRasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS)ALS is a disorder that weakens motor strength and lung function.NCT01786603Phoenix, Arizona and 9 others RecruitingExamining Interactions Between PALS and CaregiversThe goal of this clinical trial is to learn about the effect of communicative interaction on verbal communication in people with amyotrophic lateral sclerosis (ALS) and their…NCT06819124University Park, Pennsylvania CompletedSingle-Ascending-Dose Safety/Tolerability of NP001 in Amyotrophic Lateral Sclerosis (ALS)Primary objectives: To assess the safety and tolerability of ascending doses of NP001 compared to placebo in subjects with ALS.NCT01091142San Francisco, California and 2 others UnknownMusic Therapy Protocol to Support Bulbar and Respiratory Functions in ALSThis study evaluates potential of music therapy treatment to support breathing, speech, swallow and cough of persons with amyotrophic lateral sclerosis (ALS).NCT03604822Moscow and 1 other TerminatedOpen-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)This is an OLE study conducted to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and clinical effects of WVE-004 in adult participants with ALS…NCT05683860Rotterdam and 2 others

Data from ClinicalTrials.govTerms