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1–20 of 1,008
Completed
HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.
NCT05136885
·
Boston, Massachusetts
Completed
Dexpramipexole SAD/MAD Study
This Phase 1 study will explore the safety, tolerability, and pharmacokinetics of single doses ranging from 300 to 600 mg and multiple daily doses ranging from 225 mg to 300 mg…
NCT01449578
·
Overland Park, Kansas
Completed
Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis
The purpose of the study is to determine whether lithium is safe and effective in the treatment of ALS
NCT00925847
·
Paris
Unknown
Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease
Non-invasive mechanical ventilation (NIMV) is the recommended standard of care as initial therapy for patients with motor neuron disease (MND) with deterioration of the…
NCT04240925
·
Milan
Completed
Neuromuscular Transmission in Amyotrophic Lateral Sclerosis
Consistent data suggest that neuromuscular transmission is impaired in ALS patients.
NCT00847847
·
Paris
Unknown
Therapeutic Treatment of Amyotrophic Lateral Sclerosis
The goal of this study is to investigate the safety and tolerability of allogeneic Wharton's jelly-derived mesenchymal stem cells administration in the individuals with diagnosed…
NCT02881476
Active not recruiting
The Aim of the Study is to Characterize Patients Exhibiting Muscular Atrophy and Weakness Who Require a Muscle Biopsy for Diagnosis (IBM vs Atypical MND), Through an Innovative Technique Which Enables the Evaluation of the Neuromuscular Junction Involvement in Each Condition
The aim of the study is to characterize 30 patients exhibiting muscular atrophy and weakness who require a muscle biopsy for diagnosis (suspected inclusion body myopathy vs…
NCT07796776
·
Milan
Completed
Nutritional Prognostic Factors in ALS
Background.
NCT03487536
·
Bari
Withdrawn
NeuRx Diaphram Pacing System (DPS) Use in Amyotrophic Lateral Sclerosis (ALS)
The purpose of this research study is to collect more information about the use, safety, and effectiveness of the NeuRx DPS® in ALS patients.
NCT03034317
Completed
Intrathecal Transplantation of Mesenchymal Stem Cell in Patients With ALS
ALS is a debilitating disease with varied etiology characterized by rapidly progressive weakness, muscle atrophy and fasciculations, muscle spasticity, difficulty speaking…
NCT01771640
·
Tehran
Completed
Enoxacin for Amyotrophic Lateral Sclerosis (ALS)
The study will assess the safety of the drug enoxacin at specific dose levels in adults with ALS.
NCT04840823
·
Montreal, Quebec
Recruiting
Control Cohort CTRL COH
Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare disease that could be difficult to diagnose.
NCT05370079
·
Bron
Recruiting
LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons, leading to paralysis and death.
NCT07312240
·
Milan, Lombardy
Unknown
Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, devastating, neurodegenerative disease characterized by the loss of cortical, brain stem, and spinal motor neurons.
NCT03377868
Terminated
A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS)
This is a phase II study to determine the safety and tolerability of ILB®, a type of low molecular weight dextran sulfate, in patients with Motor Neurone Disease (MND)/…
NCT03705390
·
Birmingham, West Midlands
Recruiting
Testing Pulse Stimulation to Improve Motor Function in People With ALS: A Pilot Study
The goal of this clinical trial is to assess the efficacy of TPS of the motor cortex on biomarkers and clinical endpoints in patients with ALS.
NCT06681610
·
Barcelona, Catalonia
Recruiting
Lung Insufflation Capacity Training and Respiratory Function in Amyotrophic Lateral Sclerosis
The goal of this clinical trial is to determine whether lung insufflation capacity (LIC) training can help maintain respiratory function and prolong tracheostomy-free survival in…
NCT07257302
·
Kodaira, Tokyo
Recruiting
ASSESS ALL ALS Study
The ALL ALS Clinical Research Consortium is establishing research to collect a wide range of samples, clinical information and measurements from Amyotrophic Lateral Sclerosis…
NCT06578195
·
Birmingham, Alabama and 36 others
Recruiting
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal…
NCT05137665
·
Phoenix, Arizona and 11 others
Completed
Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)
MetFlex is an investigator led, open-label, single-arm, Phase 2a trial to determine the safety and tolerability of trimetazidine for the treatment of amyotrophic lateral…
NCT04788745
·
Brisbane, Queensland and 2 others
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