MIROCALS: Modifying Immune Response and OutComes in ALS

Exclusion Criteria

• •Other neurodegenerative disease that could explain signs or symptoms
• •Contra indication for lumbar puncture (history of allergy to xylocaine, presence of contra-indicated treatment, or coagulation test abnormality, clinically significant coagulopathy or thrombocytopenia)
• •Non authorized treatment
• •Other disease or disorders that could preclude functional assessment, or life-threatening disorders
• •Any documented, active, past or present, auto-immune disorders except asymptomatic Hashimoto thyroiditis
• •Using assisted ventilation
• •Feeding through gastrostomy or nasogastric tube
• •Women of child-bearing potential or sexually active man without contraception
• •Pregnant or breast feeding woman
• •Any clinically significant laboratory abnormality (excepting cholesterol, triglyceride, glucose, CK, ferritin)
• •History of documented symptomatic and treated asthma within the past 5 years